Process analytical technique ( <scp>PAT</scp> ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing

Miniaturization in Analytical Chemistry

Miniaturization is rapidly growing, with novel ideas emerging in recent years. Like other fields, analytical systems have been affected by this new technology. Concretely, the capacity to carry out laboratory operations on a small scale using miniaturized devices is very appealing. Micro total analysis systems (mTAS), also called lab-on-a-chip, have renewed interest in scaling laws in the last ...

Analytical miniaturization and nanotechnologies.

Miniaturization of analytical systems.

Miniaturization has been a long-term trend in clinical diagnostics instrumentation. Now a range of new technologies, including micromachining and molecular self-assembly, are providing the means for further size reduction of analyzers to devices with micro- to nanometer dimensions and submicroliter volumes. Many analytical techniques (e.g., mass spectrometry and electrophoresis) have been succe...

Trends in Upstream and Downstream Process Development for Antibody Manufacturing.

A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for ...

Application of radioimmunoassay technique for determination of antigen concentration in different cells with a new monoclonal antibody [Persian]

Introduction: Binding a monoclonal antibody to tumor associated antigens is an effective method for cancer therapy because these agents can specifically target malignant cells, in fact monoclonal antibodies are effective agents for diagnosis, grading and treatment of different kinds of cancers. Methods: In this research, a new monoclonal antibody against colon cancer cells was prepared an...